Canine ALK1 / ACVRL1 Protein|技术资料|现货

ALK1 / ACVRL1蛋白产品信息

别名: ACVRL1
表达方式: 
A DNA sequence encoding the canine ACVRL1(E2R174) (Met1-Gln119) was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Canine
表达宿主: Human Cells

ALK1 / ACVRL1 Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gly 22
分子量: 
The recombinant canine ACVRL1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 339 amino acids and has a predicted molecular mass of 37.9 kDa. The apparent molecular mass of the protein is approximately 43-47 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

ALK1 / ACVRL1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

ALK1 / ACVRL1蛋白背景综述

ALK1 is a type I? cell-surface receptor for the TGF-beta superfamily of ligands. The heteromeric receptor complex consists of two types (I and II) transmembrane serine/threonine kinases, among which, constitutively active Type II receptors phosphorylate and activate type I? receptors on ligand binding, and in turn, type I? kinase phosphorylates down stream signal molecules including various SMAD transcriptional regulators. ALK1 shares a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail with other activin receptor-like kinase proteins. ALK1 has been suggested to be implicated in the blood vessel development and repair. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.

参考文献

Ten Dijke P. et al., 1993, Oncogene. 8: 2879-87.
Ye-Guang Chen. et al., 1999, J Biol Chem. 274: 3672-7.
Panchenko M.P. et al., 1996, Am J Physiol. 270: 547-58.
Johnson DW. et al., 1996, Nat Genet. 13: 189-95.
Shoukier M. et al., 2008, Clin Genet. 73: 320-30.

规格：100ug

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