Rat BAFFR / TNFRSF13C Protein|报价|技术资料

BAFFR / TNFRSF13C蛋白产品信息

别名: TNFRSF13C
表达方式: 
A DNA sequence encoding the rat TNFRSF13C (D3ZNT3) (Ser10-Ala71) was expressed with a polyhistidine tag at the C-terminus.
种属: Rat
表达宿主: Human Cells

BAFFR / TNFRSF13C Protein QC Testing

纯度: > 85 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ser 10
分子量: 
The recombinant rat TNFRSF13C comprises 73 amino acids and predicts a molecular mass of 8.3 kDa. The apparent molecular mass of  the recombinant protein is approximately 20 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

BAFFR / TNFRSF13C Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

BAFFR / TNFRSF13C蛋白背景综述

Tumor necrosis factor receptor superfamily member 13C, also known as B-cell-activating factor receptor, BAFF receptor, BLyS receptor 3, CD268, TNFRSF13C and BAFFR, is a single-pass type III membrane protein which contains one?TNFR-Cys repeat. TNFRSF13C / BAFFR is highly expressed in spleen and lymph node, and in resting B-cells. It is detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes. TNFRSF13C / BAFFR is a B-cell receptor specific for TNFSF13B / TALL1 / BAFF / BLyS. TNFRSF13C / BAFFR promotes the survival of mature B-cells and the B-cell response. Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) which is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins.

参考文献

Thompson JS. et al., 2001, Science. 293 (5537): 2108-11.
Laabi Y. et al., 2002, Curr Biol. 11 (24): R1013-6.
Defrance T. et al.,2003, Adv Cancer Res. 86: 195-225.
Ambrose CM. et al., 2003, J Biol Regul Homeost.Agents. 16 (3): 211-3.

规格：50ug

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