Cynomolgus XEDAR / EDA2R / TNFRSF27 Protein|使用说明|现货

XEDAR / EDA2R / TNFRSF27蛋白产品信息

别名: EDA2R, TNFRSF27, XEDAR
表达方式: 
A DNA sequence encoding the cynomolgus EDA2R (NP_001180396.1) (Met1-Glu136) was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Cynomolgus
表达宿主: Human Cells

XEDAR / EDA2R / TNFRSF27 Protein QC Testing

纯度: (60.3+19.2+15) % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Met
分子量: 
The recombinant cynomolgus EDA2R is a disulfide-linked homodimer. The reduced monomer comprises 377 amino acids and has a calculated molecular mass of 42.1 KDa.The apparent molecular mass of the protein is approximately 116, 58 and 53 KDa respectively in SDS-PAGE.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

XEDAR / EDA2R / TNFRSF27 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

XEDAR / EDA2R / TNFRSF27蛋白背景综述

Tumor necrosis factor receptor superfamily member 27, also known as X-linked ectodysplasin-A2 receptor, EDA-A2 receptor, EDA2R, XEDAR and TNFRSF27, is a single-pass type I?II membrane protein. TNFRSF27 / EDA2R contains three?TNFR-Cys repeats. It is a new member of the tumor necrosis factor receptor family that has been shown to be highly expressed in ectodermal derivatives during embryonic development and binds to ectodysplasin-A2 (EDA-A2). TNFRSF27 / EDA2R is a receptor for EDA isoform A2, but not for EDA isoform A1. TNFRSF27 / EDA2R mediates the activation of the NF-kappa-B and JNK pathways. The activation seems to be mediated by binding to TRAF3 and TRAF6. Ectodysplasin, a member of the tumor necrosis factor family, is encoded by the anhidrotic ectodermal dysplasia EDA gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that differ only by an insertion of two amino acids. This insertion functions to determine receptor binding specificity, such that EDA-A1 binds only the receptor EDAR, whereas EDA-A2 binds only the related, but distinct, X-linked ectodysplasin-A2 receptor (XEDAR).

参考文献

Yan M. et al., 2000, Science. 290: 523-7.
Sinha SK. et al., 2002, J Biol Chem. 277: 44953-61.
Prodi DA. et al., 2008, J Invest Dermatol. 128 (9): 2268-70.

规格：50ug

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