Cynomolgus REG1A / PSPS Protein|厂家现货|参数

REG1A / PSPS蛋白产品信息

别名: REG1A
表达方式: 
A DNA sequence encoding the cynomolgus REG1A (G8F4F8) (Met1-Asn166) was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Cynomolgus
表达宿主: Human Cells

REG1A / PSPS Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gln 23
分子量: 
The recombinant cynomolgus REG1A comprises 385 amino acids and has a calculated molecular mass of 43.2 KDa. The apparent molecular mass of it is approximately 44 KDa respectively in SDS-PAGE.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

REG1A / PSPS Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

REG1A / PSPS蛋白背景综述

Lithostathine-1-alpha, also known as Pancreatic stone protein, Pancreatic thread protein, Regenerating islet-derived protein 1-alpha, REG1A, REG-1-alpha, and PSPS, is highly expressed in fetal and infant brains. REG1A contains one C-type lectin domain and is a known growth factor affecting pancreatic islet beta cells. REG1A may act as an inhibitor of spontaneous calcium carbonate precipitation. It may also be associated with neuronal sprouting in brain, and with brain and pancreas regeneration. REG1A has been reported to be expressed in human cancers, and it may be positively correlated with patient's prognosis. REG3A and REG1A proteins are both involved in liver and pancreatic regeneration and proliferation. High levels of REG1A expression by tumor cells are an independent predictor of a poor prognosis in patients with non-small cell lung cancer (NSCLC).

参考文献

Gerbaud V. et al.,2000, J Biol Chem. 275: 1057-64.
Cavard C. et al., 2006, Oncogene. 25 (4): 599-608.
Astrosini C. et al., 2008, Int J Cancer. 123 (2): 409-13.
Minamiya Y. et al., 2008, Lung Cancer. 60 (1): 98-104.
Geng J. et al., 2009 Eur J Surg Oncol. 35 (8): 852-7.

规格：50ug

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