Cynomolgus IL1R1 Protein|产品详情|现货

IL1R1蛋白产品信息

别名: IL1R1
表达方式: 
A DNA sequence encoding the cynomolgus IL1R1 (G7NAT4) (Met1-Thr332) was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Cynomolgus
表达宿主: Human Cells

IL1R1 Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Asp 21
分子量: 
The recombinant cynomolgus IL1R1 is a disulfide-linked homodimer. The reduced monomer comprises 553 amino acids and has a calculated molecular mass of 62.9 KDa.The apparent molecular mass of the protein is approximately 73-93 KDa respectively in SDS-PAGE.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

IL1R1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL1R1蛋白背景综述

Interleukin 1 receptor, type I (IL1R1), also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor that belongs to the IL-1 receptor family. IL1R1 is a receptor for both interleukin alpha (IL1A) and interleukin beta (IL1B), and also associates with interleukin-1 receptor antagonist protein (IL-1RA). There are two distinct types of receptors that bind the pleiotropic cytokines IL1A and IL1B: the type I is an 80 kDa transmembrane protein expressed predominantly by T cells, fibroblasts, and endothelial cells and appears to mediate all the known IL-1 biological functions. However, the type a… receptor is a 68 kDa transmembrane protein with a short cytoplamic domain and serves as a decoy for IL-1. IL1R1 structurally consists of three C2-type I g-like domains and one TIR domain. As important mediators involved in many immune and inflammatory responses, the agonists IL1A and IL1B bind to IL1R1, leading to the signal transduction and activation of NF-kappa-B. Formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2 is indepensible for the signaling processes. Recombinant soluble form of IL1R1 is thus a potent antagonist of IL-1 function.

参考文献

Reddy SA. et al., 1997, J Biol Chem. 272 : 29167-73.
Huang J. et al.,1997, Proc. Natl Acad Sci. 94: 12829-32.
Vigers G PA. et al., 1997, Nature. 386:190-4.
Schreuder H. et al., 1997, Nature. 386:194-200.
Vigers GPA. et al., 2000, J Biol Chem. 275: 36927-33.

规格：50ug

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