CD33 / Siglec-3 Protein|CD33 / Siglec-3蛋白质|参数|厂家现货

CD33 / Siglec-3蛋白产品信息

别名: CD33, SIGLEC3
表达方式: 
A DNA sequence encoding the human CD33 (AAH28152.1) (Met1-His259) was  fused with Fc region of mouse IgG at the C-terminus.
种属: Human
表达宿主: Human Cells

CD33 / Siglec-3 Protein QC Testing

纯度: > 90 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Asp 18
分子量: 
The recombinant human CD33/mFc is a disulfide-linked homodimer. The reduced monomer comprises 476 amino acids and has a predicted molecular mass of 53.1 kDa. The apparent molecular mass of the protein is approximately 64-68 in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CD33 / Siglec-3 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD33 / Siglec-3蛋白背景综述

Myeloid cell surface antigen CD33, also known as Sialic acid-binding Ig-like lectin 3, SIGLEC3 and CD33, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD33 / Siglec-3 contains 1 Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. CD33 / Siglec-3 is an adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. CD33 / Siglec-3 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, CD33 / Siglec-3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 / Siglec-3 induces apoptosis in acute myeloid leukemia. CD33 / Siglec-3 is becoming increasingly important as a target of antibody-mediated therapy in acute myeloid leukaemia (AML).

参考文献

Bernstein ID. et al., 2002, Clin Lymphoma. 1: S9-11.
Hauswirth AW. et al., 2007, Eur J Clin Invest. 37 (1): 73-82.
Shamsasenjan K. et al., 2009, Int J Hematol. 89 (3): 310-8.
Abdool A. et al., 2010, Exp Hematol. 38 (6): 462-71.

规格：50ug

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