LILRA3 / ILT6 Protein|LILRA3 / ILT6蛋白质|价格|参数

LILRA3 / ILT6蛋白产品信息

别名: LILRA3, ILT6, LIR4
表达方式: 
A DNA sequence encoding the human LILRA3 (AAH28208.1) (Met1-Glu439) was expressed with a polyhistidine tag at the C-terminus.
种属: Human
表达宿主: Human Cells

LILRA3 / ILT6 Protein QC Testing

纯度: > 85 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gly 24
分子量: 
The recombinant human LILRA3 consists of  427 amino acids and predicts a molecular mass of  46.5 KDa. It migrates as an approximately 57-66 KDa band in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

LILRA3 / ILT6 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

LILRA3 / ILT6蛋白背景综述

ILT6 is a member of the ILT family. ILT family proteins are expressed predominantly on myeloid lineage cells, and some members have been shown to bind classical (HLA-A and -B) and non-classical (HLA-G1, -E and -F) MHC class I molecules. Several nomenclatures exist, giving each member a different ILT, LIR, LILR, CD85 or other designation. ILT6 contains 4 Ig-like C2-type (immunoglobulin-like) domains and may act as soluble receptor for class I MHC antigens. It can be detected n B-cells, and at lower levels in natural killer (NK) cells. Unlike many of its family, ILT6 lacks a transmembrane domain. If secreted, the ILT6 might impair interactions of membrane-bound LILRs with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease.

参考文献

Wi niewski A. et al., 2004, Hum Immunol. 64 (4): 458-61.
Norman PJ. et al., 2003, Immunogenetics. 55 (3): 165-71.
Cella M. et al., 1997, J Exp Med. 185 (10): 1743-51.

规格：20ug

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