SCN2B Protein|SCN2B蛋白质|使用说明|价格|现货

SCN2B蛋白产品信息

别名: SCN2B
表达方式: 
A DNA sequence encoding the human SCN2B (O60939) (Met1-Ala159) was expressed with a polyhistidine tag at the C-terminus.
种属: Human
表达宿主: Human Cells
纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Met 30
分子量: 
The recombinant human SCN2B consists of  141 amino acids and predicts a molecular mass of  16.6 KDa. It migrates as an approximately 24-33 KDa band in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

SCN2B Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

SCN2B蛋白背景综述

SCN2B is essential for the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. Voltage-gated sodium channels (NaV) are composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits. Alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments. They are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. SCN2B interacts with TNR and may play a crucial role in clustering and regulation of activity of sodium channels at nodes of ranvier. SCN2B also causes an increase in the plasma membrane surface area and in its folding into microvilli.

参考文献

Tan BH. et al., 2010, Heart Rhythm. 7 (6): 771-8.
Watanabe H. et al., 2009, Circ Arrhythm Electrophysiol. 2 (3): 268-75.

规格：20ug

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