Mouse N-Cadherin / Cadherin 2 / CDH2 Protein|厂家|报价|参数

N-Cadherin / Cadherin 2 / CDH2蛋白产品信息

别名: CDH2, CDHN, N-cadherin, Ncad
表达方式: 
A DNA sequence encoding the mouse CDH2 (P15116) (Met1-Ala724) was fused with six amino acids (LEVLFQ) at the C- terminus was expressed and purified.
种属: Mouse
表达宿主: Human Cells

N-Cadherin / Cadherin 2 / CDH2 Protein QC Testing

纯度: (41.7+39.2)% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ser 26
分子量: 
The recombinant mouse CDH2 consists of 706 amino acids and has a calculated molecular mass of 77.8 kDa. The recombinant protein migrates as an approximately 91 and 114 kDa band in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

N-Cadherin / Cadherin 2 / CDH2 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

N-Cadherin / Cadherin 2 / CDH2蛋白背景综述

Cadherins are calcium dependent cell adhesion proteins, and they preferentially interact with themselves in a homophilic manner in connecting cells. Human cadherin 2, type 1, N-cadherin (neuronal) (NCAD) , also known as CDH2, is a single-pass tranmembrane protein and a cadherin containing 5 cadherin domains. N-cadherin displays a ubiquitous expression pattern but with different expression levels between endocrine cell types. CDH2 (NCAD) has been shown to play an essential role in normal neuronal development, which is implicated in an array of processes including neuronal differentiation and migration, and axon growth and fasciculation. In addition, N-cadherin expression was upregulated in human HSC during activation in culture, and function or expression blocking of N-cadherin promoted apoptosis. During apoptosis, N-cadherin was cleaved into 20-100 kDa fragments. N-cadherin cleavage occurred at a higher level in glioblastoma cells than in non-neoplastic astrocytes.

参考文献

LaMora A. et al., 2009, Neuroscience. 159: 1175-84.
Chauvet N. et al., 2009, J Endocrinol. 202: 375-87.
Hartland S.N. et al., 2009, Liver Int. 29: 966-78.
Kohutek Z.A. et al., 2009, J Neurosci. 29: 4605-15.

规格：50ug

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