Mouse FLT3 / FLK2 / CD135 Protein|技术资料|厂家现货

FLT3 / FLK2 / CD135蛋白产品信息

别名: FLT3
表达方式: 
A DNA sequence encoding the mouse FLT3 (EDL05833.1) (Met1-Ser544) was expressed with a C-terminal polyhistidine tag.
种属: Mouse
表达宿主: Human Cells

FLT3 / FLK2 / CD135 Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Asn 28
分子量: 
The recombinant mouse FLT3 comprises 528 amino acids and has a predicted molecular mass of 59.5 kDa. The apparent molecular mass of the protein is approximately 73 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

FLT3 / FLK2 / CD135 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

FLT3 / FLK2 / CD135蛋白背景综述

FL cytokine receptor, also known as tyrosine-protein kinase receptor FLT3, Stem cell tyrosine kinase 1, STK-1, FLT3 and CD135, is a single-pass type I  membrane protein. CD135 belongs to the protein kinase superfamily and the CSF-1/PDGF receptor subfamily. It contains one Ig-like C2-type domain and one protein kinase domain. CD135 is an important cell surface marker used to identify certain types of hematopoietic progenitors in the bone marrow. Specifically, multipotent progenitors (MPP) and common lymphoid progenitors (CLP) express surface CD135 at high levels. This marker is therefore used to differentiate hematopoietic stem cells (HSC), which are CD135 negative, from MPPs, which are CD135 positive. Signaling through CD135 plays a role in cell survival, proliferation, and differentiation. CD135 is also important for lymphocyte (B cell and T cell) development, but not for the development of other blood cells (myeloid development). Identified as a proto-oncogene, the mutations of FLTS gene are associated with certain carcinomas.

参考文献

Reilly JT. et al., 2003, Leuk Lymphoma. 44 (1): 1-7.
Marcucci G. et al., 2005, Curr Opin Hematol. 12 (1): 68-75.
Sternberg DW. et al.,2005, Curr Opin Hematol. 12 (1): 7-13.
Stubbs MC. et al., 2007, Current drug targets. 8 (6): 703-14.

规格：20ug

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