Rat Layilin / LAYN Protein|报价|厂家现货

Layilin / LAYN蛋白产品信息

别名: LAYN
表达方式: 
A DNA sequence encoding the rat LAYN (NP_001178926.1) (Met1-Glu224) was expressed with a polyhistidine tag at the C-terminus.
种属: Rat
表达宿主: Human Cells

Layilin / LAYN Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: His 25
分子量: 
The recombinant rat LAYN comprises 211 amino acids and predicts a molecular mass of 24.3 kDa. The apparent molecular mass of  the recombinant protein is approximately 34 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

Layilin / LAYN Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Layilin / LAYN蛋白背景综述

Layilin, a recently characterized transmembrane protein with homology to C-type lectins, is present in numerous cell lines and tissue extracts. As one of the adaptor proteins, talin mediates the interactions between the actin filaments and the cell membrane by binding to integral membrane proteins and to the cytoskeleton. Layilin is a newly identified membrane-binding site for talin in peripheral ruffles of spreading cells, and its adjacent LH2-LH3 tandem arrays in the cytoplasmic domain provide docking sites for talin. Layilin binds specifically to hyaluronan (HA) through its extracellular domain, a ubiquitous extracellular matrix component in most animal tissues and body fluids, but not to other tested glycosaminoglycans. All the above actions reveal an interesting parallel between layilin and the known HA receptor CD44. In addition, merlin and radixin have been identified as different intracellular binding partners of layilin. Accordingly, it has been suggested that layilin plays roles in a variety of cellular processes, including cell shape, adhesion, motility, and homeostasis, as well as signal transduction.

参考文献

Borowsky ML. et al., 1998, J Cell Biol. 143: 429-42.
Bono P. et al., 2001, Mol Biol Cell. 12: 891-900.
Rees DJG. et al., 1990, Nature. 347: 685-9.
Bono P. et al., 2005, Exp Cell Res. 308: 177-87.
Schoenwaelder SM. et al., 1999, Curr Opin Cell Biol. 11:274-86.

规格：20ug

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