Cynomolgus IFNA2 / Interferon alpha 2 Protein|参数|价格

IFNA2 / Interferon alpha 2蛋白产品信息

别名: IFNA2
表达方式: 
A DNA sequence encoding the cynomolgus IFNA2 (NP_001129266.1) (Met1-Glu188) was expressed with a polyhistidine tag at the C-terminus.
种属: Cynomolgus
表达宿主: Human Cells

IFNA2 / Interferon alpha 2 Protein QC Testing

纯度: > 90 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Cys 24
分子量: 
The recombinant cynomolgus IFNA2 comprises 176 amino acids and has a calculated molecular mass of 21 KDa. The apparent molecular mass of it is approximately 23 KDa  in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

IFNA2 / Interferon alpha 2 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IFNA2 / Interferon alpha 2蛋白背景综述

Interferon alpha 2 (IFN-alpha 2) is a member of the IFN alpha protein family. The IFN alpha proteins are produced by leukocytes. They are mainly involved in innate immune response against viral infection. IFN alpha acts as a pyrogenic factor by altering the activity of thermosensitive neurons in the hypothalamus thus causing fever. It does this by binding to opioid receptors and eliciting the release of prostaglandin-E2 (PGE2). A similar mechanism is used by IFN alpha to reduce pain; IFN alpha interacts with the μ-opioid receptor to act as an analgesic. Interferon alpha 2 (IFN-alpha 2) was isolated from a preparation of partially purified human leucocyte IFN by monoclonal-antibody immunoaffinity chromatography. Interferon alpha-2 (IFN alpha 2) is a leukocyte product with several biological properties including antiviral activity, pyrogenicity and enhancement of immune functions. It has been reported that an additional facet of Interferon alpha-2 activity is its ability to enhance slow-wave sleep (SWS) without greatly altering other aspects of sleep. The sleep-promoting activity of Interferon alpha-2 may be related to feelings of lassitude and sleepiness that often accompany viral disease and interferon therapy. Recombinant alpha-2 interferon has been used in the treatment of Kaposi's sarcoma, and its toxicity and efficacy is associated with the acquired immunodeficiency syndrome.

参考文献

Wang. et al., 2004, J Neuroimmunol. 156 (1-2): 107-12.
Groopman JE. et al., 1984, Ann Intern Med. 100 (5): 671-6.
Krueger JM. et al., 1987, Int J Immunopharmacol. 9 (1): 23-30.

规格：20ug

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