Cynomolgus B7-1 / CD80 Protein|厂家现货|参数

B7-1 / CD80蛋白产品信息

别名: CD80
表达方式: 
A DNA sequence encoding the cynomolgus CD80 (AAC31555.1) (Met1-Asn242) was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Cynomolgus
表达宿主: Human Cells

B7-1 / CD80 Protein QC Testing

纯度: (89.4+9.8) % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Val 35
分子量: 
The recombinant cynomolgus CD80 is a disulfide-linked homodimer. The reduced monomer comprises 449 amino acids and has a calculated molecular mass of 50.9 KDa.The apparent molecular mass of the protein is approximately 65 and 44 KDa respectively in SDS-PAGE.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

B7-1 / CD80 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

B7-1 / CD80蛋白背景综述

T-lymphocyte activation antigen CD80, also known as Activation B7-1 antigen, CTLA-4 counter-receptor B7.1, BB1, CD80 and CD28LG, is a single-pass type I membrane protein which is expressed on activated B-cells, macrophages and dendritic cells.CD80 / CD28LG contains one?Ig-like C2-type (immunoglobulin-like) domain and Ig-like V-type (immunoglobulin-like) domain. CD80 / CD28LG is involved in the costimulatory signal essential for T-lymphocyte activation. CD80 / CD28LG is a very potent co-stimulatory factor which is required for complete T-cell activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor.

参考文献

Zhang H. et al., 2000, Biochim Biophys Acta. 1490 (3): 342-7.
Sabzevari H. et al., 2001, J Immunol.166 (4): 2505-13.
Li DC. et al., 2006, World J Gastroenterol. 12 (6): 880-4.

规格：100ug

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