Cynomolgus CD4 Protein|技术资料|现货

CD4蛋白产品信息

别名: CD4
表达方式: 
A DNA sequence encoding the cynomolgus CD4 (G7N5T8) (Met1-Trp390) was expressed with a polyhistidine tag at the C-terminus.
种属: Cynomolgus
表达宿主: Human Cells

CD4 Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Lys 26
分子量: 
The recombinant cynomolgus CD4 comprises 376 amino acids and has a calculated molecular mass of 41.8 KDa. The apparent molecular mass of it is approximately 48-53 KDa  in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CD4 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD4蛋白背景综述

T-cell surface glycoprotein CD4, also known as T-cell surface antigen T4/Leu-3, is a single-pass type I  membrane protein. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is a glycoprotein expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 before being named CD4 in 1984. CD4 is a co-receptor that assists the T cell receptor (TCR) to activate its T cell following an interaction with an antigen presenting cell. Using its portion that resides inside the T cell, CD4 amplifies the signal generated by the TCR. CD4 interacts directly with MHC class II molecules on the surface of the antigen presenting cell via its extracellular domain. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors. Therefore, medical professionals refer to the CD4 count to decide when to begin treatment for HIV-infected patients.

参考文献

Ryu SE. et al., 1994, Structure 2 (1): 59-74.
Isobe M. et al., 1986, Proc. Natl. Acad. Sci. 83 (12): 4399-402.
Ansari-Lari MA. et al., 1996, Genome Res. 6 (4): 314-26.
Hawash. et al., 2002, Biochim Biophys Acta. 1589 (2): 140-50.

规格：50ug

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