Rat LAG3 / CD223 / Lymphocyte activation gene 3 Protein|厂家现货|报价

LAG3 / CD223 / Lymphocyte activation gene 3蛋白产品信息

别名: LAG3
表达方式: 
A DNA sequence encoding the rat LAG3 (Q5BK54)(Met1-Leu442) was expressed with a polyhistidine tag at the C-terminus.
种属: Rat
表达宿主: Human Cells

LAG3 / CD223 / Lymphocyte activation gene 3 Protein QC Testing

纯度: > 90 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gly 24
分子量: 
The recombinant rat LAG3 comprises 430 amino acids and predicts a molecular mass of 47.1 kDa. The apparent molecular mass of  the recombinant protein is approximately 55 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

LAG3 / CD223 / Lymphocyte activation gene 3 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

LAG3 / CD223 / Lymphocyte activation gene 3蛋白背景综述

LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells. It also acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signalling, leading to increased antigen-specific T-cell responses in vivo.

参考文献

Sigrid Hannier. et al., 1998, The Journal of Immunology. 161(8): 4058-65.
Triebel F. et al., 1990, J Exp Med. 171 (5): 1393-405.
Baixeras E. et al., 1992, J Exp Med. 176 (2): 327-37.
Huard B. et al., 1997, Proc Natl Acad Sci. 94 (11): 5744-9.
Kisielow M. et al., 2005, Eur J Immunol. 35 (7): 2081-8.

规格：50ug

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