Cynomolgus CLEC5A / MDL1 / MDL-1 Protein|厂家现货|技术资料

CLEC5A / MDL1 / MDL-1蛋白产品信息

别名: CLEC5A
表达方式: 
A DNA sequence encoding the cynomolgus CLEC5A (F7GAV1) (Pro28-Arg188) was expressed with a polyhistide tag at the N-terminus.
种属: Cynomolgus
表达宿主: Human Cells

CLEC5A / MDL1 / MDL-1 Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: His
分子量: 
The recombinant heterodimer of cynomolgus CLEC5A comprises 181 amino acids and has a calculated molecular mass of 21 KDa. The apparent molecular mass of the protein is approximately 38 KDa respectively in SDS-PAGE.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CLEC5A / MDL1 / MDL-1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CLEC5A / MDL1 / MDL-1蛋白背景综述

CLEC5A, also known as MDL1 and MDL-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. CLEC5A with dnax-activation protein 12 and may play a role in cell activation. It also functions as a positive regulator of osteoclastogenesis. CLEC5A acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation .The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.

参考文献

Chen ST. et al., 2008, Nature. 453 (7195): 672-6.
Davila S. et al., 2010, Genes Immun. 11 (3): 232-8.
Hillier LW. et al., 2003, Nature. 424 (6945): 157-64.

规格：10ug

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