ErbB3 / HER3蛋白产品信息
别名: ErbB3,HER3,LCCS2,ErbB-3,c-erbB3,erbB3-S,MDA-BF-1,MGC88033
表达方式:
A DNA sequence encoding the human ErbB3 (NP_001973.2) (Met1-Thr643)was fused with Fc region of mouse IgG at the C-terminus.
种属: Human
表达宿主: Human Cells
ErbB3 / HER3 Protein QC Testing
纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ser 20
分子量:
The recombinant human ErbB3/mFc is a disulfide-linked homodimer. The reduced monomer comprises 858 amino acids and has a predicted molecular mass of 95 kDa. The apparent molecular mass of the protein is approximately 119-129 in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
ErbB3 / HER3 Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
ErbB3 / HER3蛋白背景综述
ErbB3, also known as Her3 (human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.
参考文献
Kraus MH. et al., 1989, Proc Natl Acad Sci. 86: 9193-7.
Carraway K.L. et al., 1994, J Biol Chem. 269: 14303-6.
Wallasch C. et al., 1995, EMBO J. 14: 4267-75.
Alimandi M. et al., 1995, Oncogene. 10: 1813-21.
Gamett DC. et al., 1995, J Biol Chem. 270: 19022-7.
Katoh M. et al., 1993, Biochem Biophys Res Commun.192: 1189-97.
规格：50ug
关 键 词：ErbB3 / HER3 Protein,ErbB3 / HER3蛋白质,报价,产品详情，实验室耗材，生化试剂，上海创赛，博飞美科，实验仪器，厂家
CANSPEC品质提供的ErbB3 / HER3 Protein |ErbB3 / HER3蛋白质|报价|产品详情性能**，其优良的品质满足您不同实验的多种需求。
本产品由上海创赛品质提供，欢迎咨询国内免费服务专线：400-608-7598，更多产品信息请登录www.canspecsci.com 或 www.4006087598.com
