Neuropilin 2 / NRP2蛋白产品信息
别名: NRP2, VEGF165R2
表达方式:
A DNA sequence encoding the human NRP2 (NP_003863.2)(Met1-Tyr855) was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Human
表达宿主: Human Cells
Neuropilin 2 / NRP2 Protein QC Testing
纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gln 23
分子量:
The recombinant human NRP2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 1072 amino acids and has a predicted molecular mass of 120.7 kDa. The apparent molecular mass of the protein is approximately 119-129 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
Neuropilin 2 / NRP2 Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Neuropilin 2 / NRP2蛋白背景综述
Neuropilin-2 (NRP-2) which is related to NRP-1, is a type I? transmembrane glycoprotein and has the structure characteristic with five main extracellular domains: two complement binding (CUB) domains, two coagulation factor V/VIII homology domains, and a MAM (meprin, tyrosine phosphatase domain) region. NRP-2 is a receptor capable of binding two disparate ligands, classⅢ semaphorins (SEMA) and vascular endothelial growth factors (VEGF), and thus regulates two diverse systems by activating cellular signaling pathways via interacting with other cell surface receptors such as VEGF receptors and plexins. NRP-2 is well known for its role in facilitating axonal guidance during the development of the neuronal system, and additionally, it is also expressed in vascular endothelial cells and lymphatic endothelium where it affects proliferation, migration, angiogenesis, as well as formation of small lymphatic vessels and capillaries. Recent study has identified NRP-2 as a polysialylated protein expressed in human dendritic cells and modulates DC-T cell Interactions. Nearly all tumor cells express neuropilins and NRP-2 is predominantly expressed in neuronal tumors and melanomas. Furthermore, it is suggested that as the specific ligand for NRP-2, SEMA 3F inhibits tumor angiogenesis and metastasis.
参考文献
Chen H. et al., 1997, Neuron. 19: 547-59.
Bielenberg DR. et al., 2006, Exp Cell Res. 312: 584-93.
Yuan L. et al., 2002, Development. 129: 4797-806.
Benoit F. et al., 2006, Blood. 108: 1243-50.
Sabrina C. et al., 2007, J Biol Chem. 282: 30346-56.
Gray MJ. et al., 2008, J Natl Cancer Inst. 100: 109-20.
规格：20ug
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