IL6ST / gp130 / CD130蛋白产品信息
别名: IL6RB,IL1R1, IL6ST,CD130,CDw130,GP130,IL6R-beta
表达方式:
A DNA sequence encoding the human IL6RB (NP_002175.2)(Met1-Ile618) was expressed with six amino acids (ENLYFQ) at the C- terminus.
种属: Human
表达宿主: Human Cells
IL6ST / gp130 / CD130 Protein QC Testing
纯度: > 90 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu 23
分子量:
The recombinant human IL6RB consists of 603 amino acids and predicts a molecular mass of 68.6 KDa. It migrates as an approximately 69-99 KDa band in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
IL6ST / gp130 / CD130 Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
IL6ST / gp130 / CD130蛋白背景综述
Glycoprotein 130 (gp130), also known as IL6ST, IL6R-beta and CD130, is a common signal-transducing molecule shared by the functional receptor complexes of the IL-6 family of cytokines (IL-6, IL-11, leukemia inhibitory factor (LIF), granulocyte colonystimulating factor, ciliary neurotrophic factor, and cardiotrophin-1). It belongs to the class â… cytokine receptor family, and was found in tissues such as brain, heart, thymus, spleen, kidney, lung and liver. Mouse gp130 contains five fibronectin type-III domains, and one Ig-like C2-type (immunoglobulin-like) domain. gp130 is an important part of many different types of signaling complexes. It binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. This complex of 3 proteins then homodimerizes to form a hexameric complex which can produce downstream signals. Inactivation of gp130 is lethal to mice. The mice homozygous for a knock-in mutation in gp130 ( Y757F/Y757F ) that leads to gp130-dependent signal transducers and activators of transcription (STAT) 1/3 hyperactivation develop a broad spectrum of hematopoietic abnormalities, including splenomegaly, lymphadenopathy, and thrombocytosis. gp130 is also involved in various human diseases, such as liver disease, coronary artery disease and myocardial infarction. Furthermore, gp130 is widely expressed in breast cancer cell lines and primary tumors, thus it have been implicated in constitutive STAT3 activation in breast cancer.
参考文献
Saito M. et al., 1992, J Immunol. 148 (12): 4066-71.
Murakami M. et al., 1993, Science. 260 (5115): 1808-10.
Yoshida K. et al., 1996, Proc Natl Acad Sci. 93 (1): 407-11.
Selander KS. et al., 2004, Cancer Res. 64 (19): 6924-33.
Jenkins BJ. et al., 2005, Blood. 105 (9): 3512-20.
Luchtefeld M. et al., 2007, J Exp Med. 204 (8): 1935-44.
规格：100ug
关 键 词：IL6ST / gp130 / CD130 Protein,IL6ST / gp130 / CD130蛋白质,现货,报价，实验室耗材，生化试剂，上海创赛，博飞美科，实验仪器，厂家
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