Ly108 / SLAMF6 Protein|Ly108 / SLAMF6蛋白质|厂家现货|参数

Ly108 / SLAMF6蛋白产品信息

别名: SLAMF6, KALI
表达方式: 
A DNA sequence encoding the human SLAMF6 (Q96DU3-1) (Met1-Met226) was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Human
表达宿主: Human Cells

Ly108 / SLAMF6 Protein QC Testing

纯度: (97.5+1.3)% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gln 22
分子量: 
The recombinant human SLAMF6/Fc is a disulfide-linked homodimer. The reduced monomer comprises 446 amino acids and has a predicted molecular mass of 50.1 kDa. The apparent molecular mass of the protein is approximately 63-68 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

Ly108 / SLAMF6 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Ly108 / SLAMF6蛋白背景综述

SLAM family member 6, also known as Activating NK receptor, NK-T-B-antigen, NTB-A, SLAMF6, KALI and Ly108, is a single-pass type I  membrane protein which belongs to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6 / Ly108 contains one Ig-like (immunoglobulin-like) domain. It is expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. SLAMF6 / Ly108 triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. SLAMF6 / Ly108 is a homodimer. It interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. SLAMF6 / Ly108 undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. SLAMF6 / Ly108 can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.

参考文献

Gray CW. et al., 2000, Eur J Biochem. 267 (18): 5699-710.
Bottino C. et al., 2001,J Exp Med. 194 (3): 235-46.
Valdez PA. et al., 2004, J Biol Chem. 279 (18): 18662-9.
Claus M. et al., 2007, Front Biosci. 13: 956-65.

规格：50ug

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