Canine 4-1BB / TNFRSF9 Protein|使用说明书|厂家现货

4-1BB / TNFRSF9蛋白产品信息

别名: TNFRSF9
表达方式: 
A DNA sequence encoding the canine TNFRSF9 (XP_850336.1) (Met1-Ser185) was expressed with a C-terminal polyhistidine tag.
种属: Canine
表达宿主: Human Cells

4-1BB / TNFRSF9 Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ile 24
分子量: 
The recombinant canine TNFRSF9 comprises 173 amino acids and has a predicted molecular mass of 18.4 kDa. The apparent molecular mass of the protein is approximately 28-34 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

4-1BB / TNFRSF9 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

4-1BB / TNFRSF9蛋白背景综述

Tumor necrosis factor receptor superfamily member 9, also known as 4-1BB ligand receptor, CD137, TNFRSF9 and ILA, is a single-pass type I membrane protein which is expressed on the surface of activated T-cells. 4-1BB / CD137 is a co-stimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. The glycoprotein 4-1BB is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumor necrosis factor receptor–associated factors (TRAFs), the adaptor protein which mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T-cell activation and growth, as well as monocyte proliferation and B-cell survival, and plays an important role in the amplification of T cell-mediated immune responses. In contrast, it can also enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, 4-1BB/4-1BBL co-stimulatory pathway has been shown to augment secondary CTL responses to several viruses, and meanwhile augment anti-tumor immunity. 4-1BB thus is a promising candidate for immunotherapy of human cancer.

参考文献

Alderson MR. et al., 1994, Eur J Immunol. 24:2219-27.
Ma BY. et al., 2005, Blood. 106: 2002-10.
Wen T. et al., 2002, J Immunol. 168: 4897-906.
Melero I. et al., 1997, Nat Med. 3: 682-5.
Saito K. et al., 2004, J. Biol. Chem. 14: 13555-63.
Kienzle G. et al., 2000, Int Immunol. 12: 73-82.
Li Q. et al., 2003, Immunology. 63: 2546-52.

规格：100ug

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