Cynomolgus CD160 Protein|厂家现货|价格

CD160蛋白产品信息

别名: CD160
表达方式: 
A DNA sequence encoding the cynomolgus CD160 (F7HQP2) (Met1-Leu158) was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Cynomolgus
表达宿主: Human Cells

CD160 Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gly 25
分子量: 
The recombinant cynomolgus CD160 is a disulfide-linked homodimer. The reduced monomer comprises 375 amino acids and has a calculated molecular mass of 41.8 KDa.The apparent molecular mass of the protein is approximately 47-52 KDa in SDS-PAGE.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CD160 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD160蛋白背景综述

CD160 antigen, also known as Natural killer cell receptor BY55 and CD160, is a cell membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. CD160 is a GPI-anchored lymphocyte surface receptor in which expression is mostly restricted to the highly cytotoxic CD56(dim)CD16(+) peripheral blood NK subset. CD160 is a receptor showing broad specificity for both classical and non-classical MHC class I molecules. CD160 is expressed in spleen, peripheral blood, and small intestine. Expression of CD160 is restricted to functional NK and T cytotoxic lymphocytes. CD160 acts as a co-activator receptor for CD3-induced proliferation of CD4+ CD160+ T cells isolated from inflammatory skin lesions. Unique CD4+ CD160+ lymphocyte subset may play a role in the pathogenesis of skin inflammation. Activated NK lymphocytes release a soluble form of CD160 that functionally impairs the MHC-I-specific cytotoxic CD8(+) T lymphocyte responsiveness.

参考文献

Barakonyi A. et al., 2004, J Immunol.173 (9): 5349-54.
Rabot M. et al., 2006, Transpl Immunol. 17 (1): 36-8.
Abecassis S. et al., 2007, J Invest Dermatol. 127 (5): 1161-6.
Giustiniani J. et al., 2007, J Immunol. 178 (3): 1293-300.

规格：50ug

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