Cynomolgus IL2RA Protein|技术资料|价格

IL2RA蛋白产品信息

别名: IL2RA
表达方式: 
A DNA sequence encoding the cynomolgus IL2RA (H6WS54) (Met1-Arg213) was expressed with six amino acids (LEVLFQ) at the C- terminus.
种属: Cynomolgus
表达宿主: Human Cells

IL2RA Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu 22
分子量: 
The recombinant cynomolgus IL2RA comprises 199 amino acids and has a calculated molecular mass of 22.4 KDa.The apparent molecular mass of the protein is approximately 38-42 KDa respectively in SDS-PAGE.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

IL2RA Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL2RA蛋白背景综述

Interleukin 2 receptor alpha (IL2Rα), also known as CD25 molecule, is a type I transmembrane glycoprotein with a signal peptide, an extracellular region, a transmembrane region, and a cytoplasmic domain. IL2Rα / CD25 is expressed on activated T cells and regulatory T cells, and is capable of binding IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2Rα is associated non-covelently with the IL2 receptor beta and gamma chain, and subsequently initiates the intacellular signal pathways such as MAPK or JAK/STAT. Accordingly, IL2 receptor complex mediates the IL2 effects via regulating T cell proliferation, activation and other lymphoid functions, and IL2Rα has been shown to deliver IL2 to the signaling complex and act as a regulator of signal transduction. In addition, IL2 induces IL2R transcription via an IL2-responsive enhancer, and IL2R also inhibits IL2 gene expression by activating the expression of CTLA-4 or FOXP3 via the negative feedback loops.

参考文献

Purvis SF. et al., 1992, Cell Immunol. 144: 32-42.
Rusterholz C. et al., 1999, Mol Cell Biol. 19: 2681-9.
Kim HP. et al., 2005, J Biol Chem. 280: 34042-7.
Stauber DJ. et al., 2006, Proc Natl Acad Sci. 103: 2788-93.
Fragale A. et al., 2008, J Immunol. 181: 1673-82.

规格：50ug

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