NFASC / Neurofascin蛋白产品信息
别名: NFASC
表达方式:
A DNA sequence encoding the human NFASC (O94856-12) (Met1-Gln939) was expressed with a C-terminal polyhistidine tag.
种属: Human
表达宿主: Human Cells
NFASC / Neurofascin Protein QC Testing
纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ile 25
分子量:
The recombinant human NFASC comprises 926 amino acids and has a predicted molecular mass of 104.4 kDa. The apparent molecular mass of the protein is approximately
114-119 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
NFASC / Neurofascin Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
NFASC / Neurofascin蛋白背景综述
NFASC, also known as neurofascin, belongs to the immunoglobulin superfamily, L1/neurofascin/NgCAM family. It contains 5 fibronectin type-III domains and 6 Ig-like C2-
type (immunoglobulin-like) domains. NFASC functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of
Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by
interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. NFASC links the AIS
extracellular matrix to the intracellular cytoskeleton.
参考文献
Volkmer H. et al., 1992, J Cell Biol. 118 (1): 149-61.
Burmeister M. et al., 1996, Mamm Genome. 7 (7): 558-9.
Ango F. et al., 2004, Cell. 119 (2): 257-72.
规格：50ug
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