Mouse CES3 / Carboxylesterase-3 Protein|价格|产品详情

CES3 / Carboxylesterase-3蛋白产品信息

别名: CES3, Ces1d, Ces1
表达方式: 
A DNA sequence encoding the mouse CES3 (NP_444430.2) (Met1-Glu561) was expressed with a C-terminal polyhistidine tag.
种属: Mouse
表达宿主: Human Cells

CES3 / Carboxylesterase-3 Protein QC Testing

纯度: > 90 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Tyr 19
分子量: 
The recombinant mouse CES3 comprises 554 amino acids and has a predicted molecular mass of 60.8 kDa. The apparent molecular mass of the protein is approximately 53 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
CES3 / Carboxylesterase-3 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CES3 / Carboxylesterase-3蛋白背景综述

Carboxylesterases hydrolyze esters of short-chain fatty acids and have roles in animals ranging from signal transduction to xenobiotic detoxification. In enzymology, a carboxylesterase is an enzyme that catalyzes the chemical reaction: a carboxylic ester + H2O = an alcohol + a carboxylate. Most enzymes from this group belong to the superfamily of hydrolases with alpha/beta protein fold (so called Alpha/beta hydrolase fold), specifically those acting on carboxylic ester bonds. The carboxylesterase family of evolutionarily related proteins (those with clear sequence homology to each other) includes a number of proteins with different substrate specificities, such as acetylcholinesterases. Carboxylesterase 3, also known as Liver carboxylesterase 31 homolog and CES3, is a endoplasmic reticulum lumen which belongs to the type-B carboxylesterase/lipase family. CES3 is involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. CES3 shows low catalytic efficiency for hydrolysis of CPT-11, a prodrug for camptothecin used in cancer therapeutics. CES3 is expressed in liver, colon and small intestine.

参考文献

Augusteyn RC. et al.,1969, Biochim Biophys Acta. 171 (1): 128-37.
Saito S. et al., 2003, J. Hum. Genet. 48: 249-70.
Sanghani SP. et al., 2003, Clin Cancer Res. 9: 4983-91.
Sanghani SP. et al., 2004, Drug Metab Dispos. 32: 505-11.
Chen R. et al., 2009, J Proteome Res. 8: 651-61.

规格：10ug

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