Mouse VCL / Vinculin Protein|技术资料|价格

VCL / Vinculin蛋白产品信息

别名: VCL
表达方式: 
A DNA sequence encoding the mouse VCL (NP_033528.3) (Met1-Gln1066) was expressed with a C-terminal polyhistidine tag.
种属: Mouse
表达宿主: Human Cells

VCL / Vinculin Protein QC Testing

纯度: > 90 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Met
分子量: 
The recombinant mouse VCL comprises 1077 amino acids and has a predicted molecular mass of 118.2 kDa. The apparent molecular mass of the protein is approximately 118 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

VCL / Vinculin Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

VCL / Vinculin蛋白背景综述

Vinculin (VCL), is a cytoskeletal protein that is closely related to both cell-matrix interactions and cell-cell junctions. VCL is a membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton. The protein contains an acidic N-terminal domain and a basic C-terminal domain separated by a proline-rich middle segment. This protein has multi-ligand properties and has been found to interact with a number of microfilament associated proteins, such as talin, a-actinin, paxillin and a-catenin, which reportedly bind to either the head or tail domains of vinculin. Moreover, it is believed that vinculin can serve as a dynamic link between the cytoskeleton and cell surface adhesion molecules, such as integrins and E-cadherins. Vinculin has also been implicated in the control of adhesion and motility of fibroblasts, PC12 cells and chick neuronal cells.

参考文献

Massoumi R. et al., 2001, J Cell Sci. 114 (10): 1925-34.
Turner CE. et al., 1994, J Cell Sci. 107 (6): 1583-91.
Strasser P. et al., 1993, FEBS Lett. 317: 189-194.

规格：10ug

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