Mouse OPCML / OBCAM Protein|厂家现货|价格

OPCML / OBCAM蛋白产品信息

别名: OPCML
表达方式: 
A DNA sequence encoding the mouse OPCML (NP_808574.2) (Ala5-Val313) was expressed with a C-terminal polyhistidine tag.
种属: Mouse
表达宿主: Human Cells

OPCML / OBCAM Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Thr 30
分子量: 
The recombinant mouse OPCML comprises 295 amino acids and has a predicted molecular mass of 32.7 kDa. The apparent molecular mass of the protein is approximately 44-55 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

OPCML / OBCAM Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Opioid-binding Cell Adhesion Molecule (OBCAM), also known as OPCML, is a GPI-anchored cell adhesion molecule in the plasma membrane, and contains three C2 type immunoglobulin (Ig)-like domains. OPCML also belongs to the IgLON subfamily in the Ig superfamily consisting of three members, LAMP, OBCAM, and Neurotrimin. These molecules interact homophilically and heterophilically within the family, and OBCAM acts only as heterodimers with LAMP or Neurotrimin and possibly inhibits neurite outgrowth from cerebellar granule cells. OPCML is originally identified as a neuron-specific molecule mainly expressed in cerebral cortex and hippocampus, and available evidences have suggested that it may be involved in neuronal plasticity, as well as the establishment and remodeling of neural circuits. Furthermore, the OPCML protein defects may play an important role in the carcinogenesis of cervical or ovarian cancers, and this gene is regarded as a candidate TSG (tumor suppressor gene).

参考文献

Shark KB. et al., 1995, Gene. 155: 213-7.
Reed J. et al., 2004, J Cell Sci. 117: 3961-73.
Struyk AF. et al., 1995, J Neurosci. 15: 2141-56.
Boulanger LM. et al., 2001, Curr Opin Neurobiol. 11: 568-78.
Sellar GC. et al., 2003, Nat Genet. 34: 337-43.
Ye F. et al., 2008, Cancer Invest. 26: 569-74.

规格：50ug

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