Cynomolgus EPHB1 / EPHT2 Protein|技术资料|现货

EPHB1 / EPHT2蛋白产品信息

别名: EPHB1
表达方式: 
A DNA sequence encoding the cynomolgus EPHB1 (XP_001115263.1) (Met1-Pro540) was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Cynomolgus
表达宿主: Human Cells

EPHB1 / EPHT2 Protein QC Testing

纯度: > 85 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Met 18
分子量: 
The recombinant cynomolgus EPHB1 comprises 764 amino acids and has a calculated molecular mass of 85.4 KDa.The apparent molecular mass of the protein is approximately 85-105 KDa respectively in SDS-PAGE.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

EPHB1 / EPHT2 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

EPHB1 / EPHT2蛋白背景综述

Ephrin type-B receptor 1, also known as EPH-like kinase 6, Tyrosine-protein kinase receptor EPH-2, EPHB1 and EPHT2, is a single-pass type I membrane protein which belongs to the protein kinase superfamily, tyr protein kinase family and ephrin receptor subfamily. EPHB1 / EPHT2 contains two fibronectin type-III domains, one protein kinase domain and one SAM (sterile alpha motif) domain. EPHB1 / EPHT2 is a member of the Eph family of receptor tyrosine kinases that is involved in embryonic nervous and vascular system development. Over- or underexpression of certain Eph receptors has been found in some cancer samples compared to normal tissue. The Eph family tyrosine kinase receptors and their ligands have been implicated in axon guidance and neuronal migration during development of the nervous system. EPHB1 / EPHT2 could stimulate fibroblast motility on extracellular matrix in a kinase-dependent manner, which also correlated with its association with Grb7, an adaptor molecule implicated in the regulation of cell migration. EPHB1 / EPHT2 is a receptor for members of the ephrin-B family. It binds to ephrin-B1, ephrin-B2 and ephrin-B3. EPHB1 / EPHT2 may be involved in cell-cell interactions in the nervous system. EPHB1 / EPHT2 plays an important roles in diverse biological processes including nervous system development, angiogenesis, and neural synapsis formation and maturation.

参考文献

Halladay AK. et al., 2000, Brain Res Mol Brain Res. 85 (1-2): 171-8.
Han DC. et al., 2002, J Biol Chem. 277 (47): 45655-61.
Wang JD. et al., 2007, Oncology. 73 (3-4): 238-45.
Petros TJ. et al., 2009, J Neurosci. 29 (11): 3463-74.

规格：200ug

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