Cynomolgus ACVR2B / ACTRIIB Protein|技术资料|现货

ACVR2B / ACTRIIB蛋白产品信息

别名: ACVR2B
表达方式: 
A DNA sequence encoding the cynomolgus ACVR2B (Ser28-Thr143)  was expressed with a polyhistidine tag at the C-terminus.
种属: Cynomolgus
表达宿主: Human Cells

ACVR2B / ACTRIIB Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ser 28
分子量: 
The recombinant cynomolgus ACVR2B comprises 127 amino acids and has a calculated molecular mass of 14.8 KDa. The apparent molecular mass of it is approximately 33-36 KDa  in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

ACVR2B / ACTRIIB Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

ACVR2B / ACTRIIB蛋白背景综述

Activin A receptor, type I IB, also known as ACTRIIB, or ACVR2B, is an activin type 2 receptor. Activins are dimeric growth and differentiation factors belonging to the TGF-beta superfamily. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I  (I and IB) and two type I I (II and IIB) receptors. Type I receptors are essential for signaling, and type I I receptors are required for binding ligands and for expression of type I  receptors. On ligand binding, Type I and II receptors form a stable complex, resulting in phosphorylation of type I  receptors by type I I receptors with constitutive kinase activity, and subsequently the initiates activation of downstream molecules. The activin A type I IB receptor displays a 3- to 4-fold higher affinity for the ligand than the type I I receptor. Mouse activin receptor IIB (ACVR2B) is a transmembrane proteins consisting of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane segment, a cytoplasmic domain with predicted serine/threonine specificity, and as well as a C-terminal PDZ binding motif . Mouse ACVR2B shares 99% aa sequence identity with human and rat within ECD.

参考文献

Hilden K. et al., 1994, Blood. 83: 2163-70.
Persson U. et al., 1997, J Biol Chem. 272: 21187-94.
Manova K. et al., 1995, Mech Dev. 49: 3-11.
Matzuk MM. et al., 1992, Biochem Biophys Res Commun.185: 404-13.

规格：100ug

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