FAS / TNFRSF6 / CD95蛋白产品信息
别名: FAS
表达方式:
A DNA sequence encoding the cynomolgus FAS (F6V1W6) (Met1-Asp173) was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Cynomolgus
表达宿主: Human Cells
FAS / TNFRSF6 / CD95 Protein QC Testing
纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gln 26
分子量:
The recombinant cynomolgus FAS is a disulfide-linked homodimer. The reduced monomer comprises 389 amino acids and has a calculated molecular mass of 43.8 KDa.The apparent molecular mass of the protein is approximately 47-57 KDa in SDS-PAGE.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
FAS / TNFRSF6 / CD95 Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
FAS / TNFRSF6 / CD95蛋白背景综述
Tumor necrosis factor receptor superfamily member 6, also known as Apoptosis-mediating surface antigen FAS, FASLG receptor, FAS, and CD95, is a member of the tumor necrosis factor (TNF) / nerve growth factor (NGF) receptor superfamily. FAS is highly expressed on the surface of a number of cell types including epithelial cells, hepatocytes, activated mature lymphocytes and other tumor cells. This receptor contains a death domain and has been shown to play a central role in the physiological regulation of programmed cell death (PCD, apoptosis) upon ligation of Fas ligand (Fas-L). This FAS receptor has been reported to be involved in the activation of NF-kappaB, MAPK3 / ERK1, MAPK8 / JNK, and the alternate pathways for CTL-mediated cytotoxicity. Accordingly, FAS is implicated in the pathogenesis of various malignancies and diseases of the immune system. Multiple Fas isoforms are derived from alternative spliced transcript variants, and among which, a soluble form lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoforms.
参考文献
Suda T. et al., 1993, Cell. 75: 1169-78.
Cascino I. et al., 1995, J Immunol. 154: 2706-13.
Brunner T. et al., 1995, Nature. 373: 441-4.
Hirata H. et al., 1998, J Exp Med. 187: 587-600.
Mary M. et al., 2001, J Biol Chem. 276: 4964-71.
Milhas D. et al., 2005, J Biol Chem. 280 :19836-42.
规格;50ug
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