FRZB / sFRP-3 Protein|FRZB / sFRP-3蛋白质|技术资料|现货

FRZB / sFRP-3蛋白产品信息

别名: FRZB, FIZ, FRE, FRP, FRZB1, SFRP3
表达方式: 
A DNA sequence encoding the human FRZB (NP_001454.2) (Ala32-Asn325) was expressed with a C-terminal polyhistidine tag.
种属: Human
表达宿主: Human Cells

FRZB / sFRP-3 Protein QC Testing

纯度: > 85 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ala 32
分子量: 
The recombinant human FRZB comprises 304 amino acids and has a predicted molecular mass of 34.5 kDa. The apparent molecular mass of the protein is approximately 41 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

FRZB / sFRP-3 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

FRZB / sFRP-3蛋白背景综述

FRZB also known as sFRP-3, is a secreted protein containing a domain similar to the putative Wnt-binding region of the frizzled family of transmembrane receptors. FRZB is widely expressed in ***** mammalian tissues. In the Xenopus gastrula, FRZB is regulated as a typical Spemann organizer component. FRZB also functions as a competitor for the cell-surface G-protein receptor Frizzled. It is espically important in embryonic development. Defects in FRZB gene can cause female-specific osteoarthritis (OA) susceptibility. FRZB may serve an important role in determining hip shape and may modify the relationship between hip shape and OA.

参考文献

Kongkham PN. et al., 2010, Oncogene. 29 (20): 3017-24.
Baker-Lepain JC. et al., 2012, Arthritis Rheum. 64 (5): 1457-65.
Leyns L. et al., 1997, Cell. 88 (6): 747-56.

规格：20ug

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