IL17BR / IL17RB / IL-17 Receptor B蛋白产品信息
别名: IL17BR, CRL4, EVI27
表达方式:
A DNA sequence encoding the human IL17BR (NP_061195.2) (Met1-Gly289) was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Human
表达宿主: Human Cells
IL17BR / IL17RB / IL-17 Receptor B Protein QC Testing
纯度: > 85 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Arg 18
分子量:
The recombinant human IL17BR/Fc is a disulfide-linked homodimer. The reduced monomer comprises 513 amino acids and has a predicted molecular mass of 56.9 kDa. The apparent molecular mass of the protein is approximately 67 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
IL17BR / IL17RB / IL-17 Receptor B Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
IL17BR / IL17RB / IL-17 Receptor B蛋白背景综述
Interleukin-17 receptor B, also known as IL-17 receptor B, IL-17RB, Cytokine receptor-like 4, IL-17 receptor homolog 1, Interleukin-17B receptor, IL-17B receptor, IL17RB and CRL4, is a secreted and single-pass type I membrane protein which contains one SEFIR domain. IL-17B receptor / IL17RB is expressed in several endocrine tissues, mostly in fetal and ***** liver, kidney, pancreas, testis, colon, brain and small intestine; not detected in peripheral blood leukocytes, lymphoid organs, and most cell lines. IL-17B receptor / IL17RB is a receptor for the proinflammatory cytokines IL17B and IL17E. IL-17B receptor / IL17RB does not bind to IL17 and IL17C. IL-17B receptor / IL17RB may play a role in controlling the growth and / or differentiation of hematopoietic cells. IL-17B receptor / IL17RB has also been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E.
参考文献
Shi Y. et al., 2000, J Biol Chem. 275 (25): 19167-76.
Tian E. et al., 2000, Oncogene. 19: 2098-109.
Matsumoto Y. et al., 2011, Allergol Int. 60 (1): 87-92.
Hunninghake GM. et al., 2011, BMC Pulm Med. 11: 17.
规格：50ug
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