Mouse GFRA3 / GFR-alpha-3 Protein|技术资料|厂家现货

GFRA3 / GFR-alpha-3蛋白产品信息

别名: GFRA3
表达方式: 
A DNA sequence encoding the mouse GFRA3 (NP_034410.3) (Met1-Arg379) was expressed with a C-terminal polyhistidine tag.
种属: Mouse
表达宿主: Human Cells

GFRA3 / GFR-alpha-3 Protein QC Testing

纯度: > 85 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Asn 29
分子量: 
The recombinant mouse GFRA3 comprises 362 amino acids and has a predicted molecular mass of 40.7 kDa. The apparent molecular mass of the protein is approximately 42-52 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

GFRA3 / GFR-alpha-3 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

GFRA3 / GFR-alpha-3蛋白背景综述

Basal cell adhesion molecule (BCAM) and Lutheran blood group glycoprotein (LU) are two alternatively spliced variants of a single pre-mRNA. They are type I membrane proteins of the immunoglobulin superfamily (IgSF) sharing similar structure characteristics except for the length of cytoplasmic tails. The mature 597 amino acid BCAM contains an extracellular domain composing of five Ig-like domains (two V-set and three C2-set) , a single transmembrane domain, and a 19aa cytoplasmic domain which lacks the putative Src homology 3 (SH3) binding site compared to the 59aa cytoplasmic domain present in LU. BCAM/LU has a wide tissue distribution with a predominant expression in the basal layer of the epithelium and the endothelium of blood vessel walls. As designated as CD239 recently, BCAM and LU share a significant sequence similarity with the CD146 (MUC18) and CD166, and themselves are adhesion molecules that bind laminin with high affinity. Laminins are found in all basement membranes and are involved in cell differentiation, adhesion, migration, and proliferation. It has been shown that BCAM expression is upregulated following malignant transformation in some cell types in vivo and in vitro, and BCAM is identified as a marker of epithelial ovarian cancers. In addition, BCAM interacts with integrin in sickle red cells, and thus may potentially play a role in vaso-occlusive episodes.

参考文献

Campbell IG. et al., 1994, Cancer Res. 54: 5761-5.
Parsons SF. et al., 1995, Proc Natl Acad Sci. 92: 5496-500.
Nemer WE. et al., 2001, J Biol Chem. 276: 23757-62.
Nemer WE. et al., 2007, Blood. 109: 3544-51.

规格：50ug

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