Canine IL11RA / IL-11RA / IL11Rα Protein|技术资料|价格

IL11RA / IL-11RA / IL11Rα蛋白产品信息

别名: IL11RA
表达方式: 
A DNA sequence encoding the canine IL11RA (XP_538710.4) (Met1-Leu363) was expressed with six amino acids (LEVLFQ) at the C- terminus.
种属: Canine
表达宿主: Human Cells

IL11RA / IL-11RA / IL11Rα Protein QC Testing

纯度: > 90 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Val 23
分子量: 
The recombinant canine IL11RA is a disulfide-linked homodimer. The reduced monomer comprises 348 amino acids and has a predicted molecular mass of 37.8 kDa. The apparent molecular mass of the protein is approximately 43-47 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

IL11RA / IL-11RA / IL11Rα Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL11RA / IL-11RA / IL11Rα蛋白背景综述

Interleukin-11 receptor alpha chain, also known as IL-11R-alpha, and IL11RA, is a single-pass type I membrane protein. It belongs to the type I cytokine receptor family and type 3 subfamily and contains two fibronectin type-III domains and one Ig-like C2-type (immunoglobulin-like) domain. Interleukin 11 receptor is a heterodimer composed of an interleukin 11 receptor alpha subunit and an incompletely characterized beta subunit. IL11RA is expressed in a number of cell lines, including the myelogenous leukemia cell line K562, the megakaryocytic leukemia cell line Mo7E, the erythroleukemia cell line TF1, and the osteosarcoma cell lines, MG-63 and Saos-2. It is also expressed in normal and malignant prostate epithelial cell lines. IL11RA is a receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and differentiation of skeletogenic progenitor or other mesenchymal cells.

参考文献

Chérel M. et al., 1995, Blood. 86 (7): 2534-40.
Chérel M. et al., 1996, Genomics. 32 (1): 49-53.
Van Leuven F. et al., 1996, Genomics. 31 (1): 65-70.
Li R. et al., 2001, Reproduction. 122 (4): 593-600.

规格：50ug

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