Rat TDGF1 / CRGF Protein|鼠TDGF1 / CRGF蛋白质|技术资料|价格

TDGF1 / CRGF蛋白产品信息

别名: TDGF1
表达方式: 
A DNA sequence encoding the rat TDGF1 (XP_001056317.2) (Met1-Cys143) was expressed with a polyhistidine tag at the C-terminus.
种属: Rat
表达宿主: Human Cells

TDGF1 / CRGF Protein QC Testing

纯度: (32.6+48.9) % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Phe 17
分子量: 
The recombinant rat TDGF1 comprises 138 amino acids and predicts a molecular mass of 15.5 kDa. The apparent molecular mass of  the recombinant protein is approximately 22 and 19 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

TDGF1 / CRGF Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TDGF1 / CRGF蛋白背景综述

Teratocarcinoma-derived growth factor 1, also known as Epidermal growth factor-like cripto protein CR1, CRGF, and TDGF1, is a cell membrane which contains one EGF-like domain. In humans, TDGF1 is highly expressed in germ cell tumors and in colon and mammary carcinomas. TDGF1 is a member of the epidermal growth factor-cripto FRL1 cryptic protein family and is involved in the activation of several different signaling pathways during embryonic development and cellular transformation. TDGF1 regulates the activation of several signaling pathways and controls cellular transformation in embryonic status. Patients with high TDGF1 expression were statistically susceptible to a recurrence of the disease, and showed poorer disease-free survival than those with low expression. TDGF1 is a predictive marker for metachronous metastasis in colorectal cancer (CRC) patients. It is preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. TDGF1 plays a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.

参考文献

Liguori G. et al., 1996, Mamm Genome. 7 (5): 344-8.
De la Cruz. et al., 2002, J M Hum Genet. 110 (5): 422-8.
Liguori G. et al., 1997, Mamm Genome. 8 (7): 502-5.
Miyoshi N. et al., 2010, Int J Oncol. 36 (3): 563-8.

规格：10ug

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