CD63 / Tspan-30 / Tetraspanin-30蛋白产品信息
别名: CD63
表达方式:
A DNA sequence encoding the cynomolgus CD63 (NP_001771.1) (Ala103-Val203) was expressed with a polyhistidine tag at the C-terminus.
种属: Cynomolgus
表达宿主: Human Cells
CD63 / Tspan-30 / Tetraspanin-30 Protein QC Testing
纯度: (71.5+25.3) % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ala 103
分子量:
The recombinant cynomolgus CD63 comprises 112 amino acids and has a calculated molecular mass of 13 KDa. The apparent molecular mass of it is approximately 22 and 19 KDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
CD63 / Tspan-30 / Tetraspanin-30 Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
CD63 / Tspan-30 / Tetraspanin-30蛋白背景综述
CD63 antigen, also known as Granulophysin, Lysosomal-associated membrane protein 3, Melanoma-associated antigen ME491, Ocular melanoma-associated antigen, Tetraspanin-30, CD63 and Tspan-30, is a multi-pass membrane protein which belongs to the tetraspanin (TM4SF) family. Tetraspanins comprise a large superfamily of cell surface-associated membrane proteins characterized by four transmembrane domains. Tetraspanins participate in a variety of cellular processes, like cell activation, adhesion, differentiation and tumour invasion. At the cell surface, tetraspanins form networks with a wide diversity of proteins called tetraspanin-enriched microdomains (TEMs). CD63 / Tspan-30 was the first characterized tetraspanin. In addition to its presence in TEMs, CD63 / Tspan-30 is abundantly present in late endosomes and lysosomes. CD63 / Tspan-30 is expressed in melanoma and appears to be involved in regulation of motility and adhesion of melanoma cells. CD63 / Tspan-30 is associated with early stages of melanoma tumor progression. It may play a role in growth regulation. Lack of expression of CD63 in platelets has been observed in a patient with Hermansky-Pudlak syndrome (HPS). which is a genetically heterogeneous, rare, autosomal recessive disorder characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects.
参考文献
Smith M. et al., 1997, Melanoma Res. 7 (2): S163-70.
Chen Z. et al., 2004, Int J Mol Med. 14 (4): 517-27.
Iida J. et al., 2005, J Transl Med. 3: 42.
Kllquist L. et al., 2008, Blood. 112 (8): 3444-54.
Pols MS. et al., 2009, Exp Cell Res. 315 (9): 1584-92.
规格：50ug
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