Mouse FAM3D / Oit1 Protein|技术资料|价格

FAM3D / Oit1蛋白产品信息

别名: FAM3D
表达方式: 
A DNA sequence encoding the mouse FAM3D (NP_666162.1)(Met1-Met223) was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Mouse
表达宿主: Human Cells

FAM3D / Oit1 Protein QC Testing

纯度: (62.3+28.3) % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Tyr 26
分子量: The recombinant mouse FAM3D/Fc is a disulfide-linked homodimer. The reduced monomer comprises 439 amino acids and has a predicted molecular mass of 49.1 kDa. The apparent molecular mass of the protein is approximately 54 and 29 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
           1.Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
           2.Please contact us for any concerns or special requirements.

FAM3D / Oit1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

FAM3D / Oit1蛋白背景综述

Family with sequence similarity 3 (FAM3) family is a novel cytokine-like family. There are four genes in this family, FAM3A, FAM3B, FAM3C, and FAM3D, each encoding a protein (224-235 amino acids) with a hydrophobic leader sequence. It had indicated that FAM3B/PANDER (pancreatic derived factor) is highly expressed in pancreas, and FAM3A and FAM3C in almost all tissues. FAM3D is abundantly expressed in placenta and weakly expressed in small intestine. Immunohistochemistry showed that FAM3A is expressed prominently in the vascular endothelium, particularly capillaries. FAM3A and FAM3B protein were both localized to the islets of Langerhans of the endocrine pancreas. Recombinant FAM3B protein has delayed effects on beta-cell function, inhibiting basal insulin secretion from a beta-cell line in a dose-dependent manner. FAM3C is involved in retinal laminar formation processes in vertebrates. NFATC2, SCP2, CACNA1C, TCRA, POLE, and FAM3D, were associated with narcolepsy. Some of these associations were further supported by gene expression analyses and an association study in essential hypersomnia (EHS), CNS hypersonia similar to narcolepsy.

参考文献

Zhu Y. et al., 2002, Genomics. 80(2): 144-50.
Katahira T. et al.,2010, Biochem Biophys Res Commun. 392 (3): 301-6.
Shimada M. et al., 2010, Hum Genet. 128(4): 433-41.

规格：50ug

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