Rat CD63 / Tspan-30 / Tetraspanin-30 Protein|鼠CD63 / Tspan-30 / Tetraspanin-30蛋

CD63 / Tspan-30 / Tetraspanin-30 Protein Product Information

Synonym : CD63
Protein Construction: 
A DNA sequence encoding the rat CD63 (P28648) (Ala103-Val203) was expressed with a polyhistidine tag at the N-terminus.
Source: Rat
Expression Host: Human Cells

CD63 / Tspan-30 / Tetraspanin-30 Protein QC Testing

Purity: (25.6+25.0+35.9) % as determined by SDS-PAGE SDS-PAGE
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: His
Molecular Mass: 
The recombinant rat CD63 comprises 121 amino acids and has a predicted molecular mass of 13.8 kDa. The apparent molecular mass of the protein is approximately 24, 19, 15 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation: Lyophilized from sterile PBS, pH 7.4.
                  1.Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
                  2.Please contact us for any concerns or special requirements.

CD63 / Tspan-30 / Tetraspanin-30 Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD63 / Tspan-30 / Tetraspanin-30 Protein Description

CD63 antigen, also known as Granulophysin, Lysosomal-associated membrane protein 3, Melanoma-associated antigen ME491, Ocular melanoma-associated antigen, Tetraspanin-30, CD63 and Tspan-30, is a multi-pass membrane protein which belongs to the tetraspanin (TM4SF) family. Tetraspanins comprise a large superfamily of cell surface-associated membrane proteins characterized by four transmembrane domains. Tetraspanins participate in a variety of cellular processes, like cell activation, adhesion, differentiation and tumour invasion. At the cell surface, tetraspanins form networks with a wide diversity of proteins called tetraspanin-enriched microdomains (TEMs). CD63 / Tspan-30 was the first characterized tetraspanin. In addition to its presence in TEMs, CD63 / Tspan-30 is abundantly present in late endosomes and lysosomes. CD63 / Tspan-30 is expressed in melanoma and appears to be involved in regulation of motility and adhesion of melanoma cells. CD63 / Tspan-30 is associated with early stages of melanoma tumor progression. It may play a role in growth regulation. Lack of expression of CD63 in platelets has been observed in a patient with Hermansky-Pudlak syndrome (HPS). which is a genetically heterogeneous, rare, autosomal recessive disorder characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defect.

规格：50ug

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