Cynomolgus DPPIV / DPP4 Protein |使用说明|价格

DPPIV / DPP4 Protein Product Information

Synonym : DPP4
Protein Construction: 
A DNA sequence encoding the cynomolgus DPP4 (F6VRB0) (Asp34-Pro766) was expressed with the Fc region of human IgG1 at the C-terminus.
Source: Cynomolgus
Expression Host: Human Cells

DPPIV / DPP4 Protein QC Testing

Purity: > 90 % as determined by SDS-PAGE SDS-PAGE
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Glu
Molecular Mass: 
The recombinant cynomolgus DPP4 is a disulfide-linked homodimer. The reduced monomer comprises 993 amino acids and has a calculated molecular mass of 112.9 KDa.The apparent molecular mass of the protein is approximately 113 KDa in SDS-PAGE.
Formulation: Lyophilized from sterile 25 mM MES, 0.7 M NaCl, pH 4.9.
                 1.Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
                 2.Please contact us for any concerns or special requirements.

DPPIV / DPP4 Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

DPPIV / DPP4 Protein Description

Dipeptidyl Peptidase IV (DPPIV)/CD26, is a highly conserved type I I integral membrane protein associated with immune regulation, signal transduction and apoptosis, and is constitutively expressed on a wide variety of epithelial, endothelial, and lymphoid cell types. DPPIV is a serine exopeptidase catalyzing the cleavage of N-terminal Xaa-Pro dipeptides from peptides, and its substrates include growth factors, chemokines, neuropeptides, and vasoactive peptides. As a T cell-activating molecule (THAM), DPPIV plays important roles in the T cell-mediated immune responses through the regulation of differentiation and growth of T lymphocytes , and also probably acts as a cofactor for entry of HIV in CD4+ cells. Furthermore, DPPIV appears to work as a suppressor in the progression of certain tumors, and also exerts actions in glucose metabolism via interaction with glucagons. DPPIV also binds the enzyme adenosine deaminase specifically with high affinity. Elevated expression of DPPIV is associated with autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. The levels of DPPIV soluble form in serum and body fluids have clinical significance in patients with cancer, liver, kidney diseases and depression.

规格：10ug

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