CD177 / PRV-1 / PRV1 Protein|技术资料|现货

CD177 / PRV-1 / PRV1 Protein Product Information

Synonym : CD177, NB1, PRV1
Protein Construction: A DNA sequence encoding the human CD177 (AAH29167.1) (Met1-Gly407) was expressed with a C-terminal polyhistidine tag.
Source: Human
Expression Host: Human Cell

CD177 / PRV-1 / PRV1 Protein QC Testing

Purity: > 95 % as determined by SDS-PAGE SDS-PAGE
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Leu 22
Molecular Mass: The recombinant human CD177 comprises 397 amino acids and has a predicted molecular mass of 42.7 kDa. The apparent molecular mass of the protein is approximately 53 kDa in SDS-PAGE under reducing conditions.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CD177 / PRV-1 / PRV1 Protein Usage Guide

Storage:  Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:  A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD177 / PRV-1 / PRV1 Protein Description

CD177, also known as PRV-1 and PRV1, is highly expressed in normal bone marrow and weakly expressed in fetal liver. PECAM-1 is a binding partner of CD177. Monoclonal antibodies against CD177 and against PECAM-1 domain 6 inhibited adhesion of U937 cells stably expressing CD177 to immobilized PECAM-1. Transendothelial migration of human neutrophils was also inhibited by these antibodies. This interaction may constitute a new pathway that participates in neutrophil transmigration.

References

Stroncek D. 2003, Vox Sang. 83 (1): 359-61.
Kissel K. et al., 2001, Eur J Immunol. 31 (5): 1301-9.
Kissel K. et al,. 2002, Blood. 99 (11): 4231-3.
Pliyev BK. et al., 2012, Eur J Haematol. 89 (3): 236-44.

规格：50ug

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