IL22RA1 / IL22R Protein Product Information
Synonym : IL22RA1
Protein Construction: A DNA sequence encoding the canine IL22RA1 (XP_855113.2) (Met1-Thr226) was expressed with the Fc region of human IgG1 at the C-terminus.
Source: Canine
Expression Host: Human Cell
IL22RA1 / IL22R Protein QC Testing
Purity: > 85 % as determined by SDS-PAGE SDS-PAGE
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Ala 15
Molecular Mass: The recombinant canine IL22RA1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 453 amino acids and has a predicted molecular mass of 51.2 kDa. The apparent molecular mass of the protein is approximately 56 kDa in SDS-PAGE under reducing conditions.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
IL22RA1 / IL22R Protein Usage Guide
Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
IL22RA1 / IL22R Protein Description
IL22 receptor (IL22 Rα1) is an approximately 65 kDa single-pass type I transmembrane glycoprotein belonging to the type I I cytokine receptor family (CRF). IL22Rα1 contains a 211 aa extracellular domain (ECD) with two fibronectin type I II repeats, and a 323 aa cytoplasmic domain. IL-22 Rα1 associates with either IL-10 Rβ or IL-20 Rβ to form receptor complexes with distinct ligand selectivities. IL-10 Rβ is a shared subunit of the IL-10, -22, -26, -28, and -29 receptors, while IL-20 Rβ is a shared subunit of the IL-19, -20, -22 R and -24 receptors. IL22 binding to heterodimer is greater than binding to IL22Rα1 alone, and the interaction can induce activation of JAK/STAT, MAPK1/MAPK3 and Akt kinase pathways. IL22Rα1 is expressed in colon, liver, lung, pancreas, kidney, keratinocytes of normal skin, and also be detected in normal blood brain barrier endothelial cells as well as in multiple sclerosis lesions.
References
Langer JA. et al., 2004, Cytokine Growth Factor Rev. 15: 33.
Dumoutier L. et al., 2001, J Immunol. 167: 3545-9.
Parrish-Novak J. et al. 2002, J Biol Chem. 277: 47517-23.
Ramesh R. et al., 2003, Cancer Res. 63: 5105-13.
Wolk K. et al., 2004, Immunity. 21: 241-54.
Boniface K. et al., 2007, Clin Exp Immunol. 150: 407-15.
Kebir H. et al., 2007, Nat Med. 13: 1173-5.
规格：50ug
关 键 词：Canine IL22RA1 / IL22R Protein,技术资料,厂家现货，实验室耗材，生化试剂，上海创赛，博飞美科，实验仪器，厂家
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