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用一滴血来评估肿瘤**
A Drop of Blood May Help Assess Cancer Therapy
用一滴血来评估肿瘤**

04.12.09, 08:00 PM EDT

Technique could one day quickly detect if treatment is working,study suggests

MONDAY, April 13 (HealthDay News) -- A specialized technique thatcan detect subtle changes in cancer cells contained in a drop ofblood or a tiny piece of tissue may one day be used by doctors tobetter assess how cancers are responding to treatment, say U.S.researchers.

"Currently, we don't know what's going on in a patient's actualtumor cells when a treatment is given. The standard way we measureif a treatment is working is to wait several weeks to see if thetumor mass shrinks. It would really be a leap forward if we coulddetect what is happening at the cellular level," lead author Dr.Alice Fan, a clinical instructor in the oncology division at theStanford University School of Medicine in California, said in aschool news release.

"This technology allows us to analyze cancer-associated proteins ona very small scale," senior study author Dr. Dean Felsher, anassociate professor of medicine and of pathology, said in the newsrelease. "Not only can we detect picogram levels -- one-trillionthof a gram -- of protein, but we can also see very subtle changes inthe ways the protein is modified."

Variations in the way a protein is modified can affect how itfunctions in tumor progression. Cancer cells can dodge commontherapies by changing their levels of protein expression anddegrees of modification, according to background information in thenews release.

The ability to continuously analyze small samples from cancerpatients undergoing treatment may help doctors identify "rogue"cells before they can create a more treatment-resistant tumor. Thistechnology could also help identify patients with cancers that areresistant to standard treatments.

Tests showed the technique was effective in samples of bloodcancers, and the researchers hope it will also help track solidtumors. The Stanford team collaborated with researchers from CellBiosciences, which makes the machine used in the study.

The study is in the April 12 online issue of the journal NatureMedicine.

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原文

Nature Medicine
Published online: 12 April 2009 | doi:10.1038/nm.1903

Nanofluidic proteomic assay for serial analysis of oncoproteinactivation in clinical specimens

Alice C Fan, at al.
Stanford University, School of Medicine, Division of Oncology,Departments of Medicine and Pathology, Stanford, California,USA.
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