APC Mouse Anti-Human CD335 (NKp46)

产品名称:APC 小鼠抗人 CD335 (NKp46) 抗体；APC Mouse Anti-Human CD335 (NKp46)

中文名称:APC 小鼠抗人 CD335 (NKp46) 抗体

英文名称:APC Mouse Anti-Human CD335 (NKp46)

APC Mouse Anti-Human CD335 (NKp46) 产品介绍：

Material Number: 558051
Size: 100 tests
Vol. per Test: 20 µl
Clone: 9E2/Nkp46
Isotype: Mouse (BALB/c) IgG1, κ
Reactivity: QC Testing: Human
Storage Buffer: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.

APC Mouse Anti-Human CD335 (NKp46) Description：

The 9E2/Nkp46 monoclonal antibody specifically binds to CD335. CD335 is also known as the Natural killer cell p46-related protein
(NKp46) and the Natural cytotoxicity triggering receptor 1 (NCR1). CD335 is a 46 kDa type I membrane glycoprotein that is expressed on
resting and activated NK cells. Its extracellular region contains two C2-type, Ig-like domains. The transmembrane domain contains a
positively charged amino acid (Arg) which could be involved in stabilizing the association with CD3ζ. Its intracellular region does not contain
immunoreceptor tyrosine-based activating motifs (ITAM), but it is linked to intracytoplasmic transduction machinery by its association with
CD3ζ and FcεRIγ adaptor proteins. CD335 along with NKp30 and NKp44 are referred to as natural cytotoxicity receptors (NCR). These
receptors play very important roles in cells that kill virus-infected target cells, tumor cells and MHC-class I-unprotected cells.

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated to APC under optimum conditions, and unconjugated antibody and free APC were removed.