700 Rat anti-Mouse CD11b

产品名称:700 大鼠抗小鼠 CD11b 抗体；700 Rat anti-Mouse CD11b

中文名称:700 大鼠抗小鼠 CD11b 抗体

英文名称:700 Rat anti-Mouse CD11b

700 Rat anti-Mouse CD11b 产品介绍：

Material Number: 557960
Alternate Name: Integrin α[M] chain, Mac-1 α chain, CR3 α chain
Size: 0.1 mg
Concentration: 0.2 mg/ml
Clone: M1/70
Immunogen: Mouse splenic Cells
Isotype: Rat (DA) IgG2b, κ
Reactivity: QC tested: Mouse
Reported: Human
Storage Buffer: Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium
azide.

700 Rat anti-Mouse CD11b Description：

The M1/70 antibody reacts with the 170-kDa α[M] chain of Mac-1 (CD11b/CD18, α[M]β[2] integrin), also known as complement receptor 3
(CR3), which mediates adhesion to C3bi and ICAM-1 (CD54). Mac-1 is expressed at varying levels on granulocytes, macrophages,
myeloid-derived dendritic cells, natural killer cells, microglia, and B-1 cells. Mac-1 expression is rapidly up-regulated on neutrophils after
activation, in the same time period that CD62L (L-selectin) is shed from the cell surface. M1/70 antibody reportedly blocks cell adherence
and C3bi binding, but it does not block cell-mediated lysis. Cross-reaction of mAb M1/70 with CD11b on human monocytes,
polymorphonuclear leukocytes, and NK cells has been reported.

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.