FITC Mouse Anti-Human CD279

产品名称:FITC 小鼠抗人 CD279 抗体；FITC Mouse Anti-Human CD279

中文名称:FITC 小鼠抗人 CD279 抗体

英文名称:FITC Mouse Anti-Human CD279

FITC Mouse Anti-Human CD279 产品介绍：

Material Number: 557860
Alternate Name: PD-1
Size: 0.1 mg
Concentration: 0.5 mg/ml
Clone: MIH4
Isotype: Mouse IgG1, κ
Reactivity: QC Testing: Human
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.



FITC Mouse Anti-Human CD279 Description：

Reacts with the program death 1 (PD-1) receptor CD279, a member of the Ig superfamily. CD279 is an immunoregulatory receptor expressed 
on activated T cells, B cells and myeloid cells. Mice deficient in CD279 show a breakdown of peripheral tolerance and manifest multiple 
autoimmune symptoms. It contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region. PD-L1 and PD-L2 
are ligands of CD279 and are members of the B7 gene family. Interaction of CD279:PD-Ligands results in inhibition of T cell proliferation 
and cytokine secretion. Reports suggest that the B7/CTLA-4 pathway functions primarily to attenuate, limit, and/or terminate naïve T-cell 
activation in secondary lymphoid organs. The PD-ligand:CD279 pathway, on the other hand, may primarily attenuate, limit, and/or terminate 
T-, B-, and myeloid cell activation/effector function at sites of inflammation in the periphery

The antibody was conjugated with FITC under optimum conditions, and unreacted FITC was removed.
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography