APC-Cy™7 Mouse Anti-Human CD19

产品名称:APC-Cy™7 小鼠抗人 CD19 抗体；APC-Cy™7 Mouse Anti-Human CD19

中文名称:APC-Cy™7 小鼠抗人 CD19 抗体

英文名称:APC-Cy™7 Mouse Anti-Human CD19

APC-Cy™7 Mouse Anti-Human CD19 产品介绍：

Material Number: 557791
Size: 100 tests
Vol. per Test: 5 µl
Clone: SJ25C1
Isotype: Mouse IgG1, κ
Reactivity: QC Testing: Human
Workshop: II L17; III 073
Storage Buffer: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.



APC-Cy™7 Mouse Anti-Human CD19 Description：

The SJ25C1 antibody reacts with CD19, a B lymphocyte-lineage differentiation antigen. CD19, a 90-kDa transmembrance glycoprotein, is a 
member of the immunoglobulin superfamily and is expressed throughout B-lymphocyte development from the pro-B cell through the mature 
B-cell stages. Terminally differentiated plasma cells do not express CD19. On the surface of mature B cells, the CD19 molecule associates 
with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to promote cellular 
activation. Studies with CD19-deficient mice have suggested that the level of CD19 expression affects the generation and maturation of B cells 
in the bone marrow and periphery. B-1 lineage B cells, also known as CD5+ B cells, are drastically reduced or absent in CD19-deficient mice. 
Increased levels of CD19 expression correlate with increased frequencies of peritonal and splenic B-1 cells and reduced numbers of 
conventional B lymphocytes in the periphery. CD19 participates in B-lymphocyte development, B-cell activation, maturation of memory B 
cells and regulation of tolerance. CD19 has also been detected on peritoneal mast cells, co-localized with CD21/CD35, and it is proposed to 
play a role in complement-mediated mast-cell activation.

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with APC-Cy7 under optimum conditions, and unconjugated antibody and free APC-Cy7 were removed.
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze