APC-Cy™7 Hamster Anti-Mouse CD3e Product Informati

产品名称:APC-Cy™7 仓鼠抗小鼠 CD3e Product Informati 抗体；APC-Cy™7 Hamster Anti-Mouse CD3e Product Informati

中文名称:APC-Cy™7 仓鼠抗小鼠 CD3e Product Informati 抗体

英文名称:APC-Cy™7 Hamster Anti-Mouse CD3e Product Informati

APC-Cy™7 Hamster Anti-Mouse CD3e Product Informati 产品介绍：

Material Number: 557596
Alternate Name: CD3ε chain
Size: 0.1 mg
Concentration: 0.2 mg/ml
Clone: 145-2C11
Immunogen: H-2Kb specific cytotoxic T lymphocyte clone BM10-37
Isotype: Armenian Hamster IgG1, κ
Reactivity: QC Testing: Mouse
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.

The 145-2C11 antibody reacts with the 25-kDa ε chain of the T-cell receptor-associated CD3 complex, which is expressed on thymocytes, 
mature T lymphocytes, and NK-T cells. The cytoplasmic domain of CD3e participates in the signal transduction events which activate several 
cellular biochemical pathways as a result of antigen recognition. Soluble 145-2C11 antibody can activate either unprimed (naive) or primed 
(memory/preactivated) T cells in vivo or in vitro, in the presence of Fc receptor-bearing accessory cells. In contrast, plate-bound 145-2C11 can 
activate T cells in the absence of accessory cells. Soluble 145-2C11 antibody has been reported to induce re-directed lysis of Fc 
receptor-bearing target cells by CTL clones and can also block lysis of specific target cells by antigen-specific CTL's. Under some conditions, 
T-cell activation by 145-2C11 antibody has been reported to result in apoptotic cell death. The 145-2C11 antibody does not cross-react with 
rat leukocytes and it has been reported that pre-incubation of thymus cell suspensions at 37°C for 2-4 hours prior to staining enhances the 
ability of anti-CD3ε and anti-αβ TCR mAbs to detect the T-cell receptor on immature thymocytes.

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with APC-Cy7 under optimum conditions, and unconjugated antibody and free APC-Cy7 were removed.
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.