Biotin Rat Anti-Mouse CD103

产品名称:Biotin 大鼠抗小鼠 CD103 抗体；Biotin Rat Anti-Mouse CD103

中文名称:Biotin 大鼠抗小鼠 CD103 抗体

英文名称:Biotin Rat Anti-Mouse CD103

Biotin Rat Anti-Mouse CD103 产品介绍：

Material Number: 557493
Alternate Name: Integrin αIEL chain
Size: 0.1 mg
Concentration: 0.5 mg/ml
Clone: M290
Immunogen: Mouse mammary tumor cells
Isotype: Rat (LOU) IgG2a, κ
Reactivity: QC Testing: Mouse
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.

The M290 antibody reacts with the α chain of αIELβ7 integrin. CD103 has a unique and fairly restricted tissue distribution. It is expressed on 
almost all intestinal intraepithelial lymphocytes (IEL), on dendritic epidermal T cells (DEC), on subpopulations of peripheral T cells, and on 
distinct subsets of fetal, neonatal, and ***** thymocytes. E-cadherin is the epithelial-cell ligand for αIELβ7 integrin. The ordered expression of 
αIEL during thymocyte development (which occurs under the influence of the thymic epithelium), the high level of expression of αIEL on 
those peripheral T cells found in epithelial tissues (IEL and DEC), and the expression of CD103 on a subset of CD8+ lymphocytes responding 
to allogeneic epithelial cells suggest that αIELβ7 integrin may have a common role in the interactions of T lymphocytes with epithelia during 
T-cell maturation and effector functions. CD103 is thought to play a role in allograft rejection. The M290 antibody is reported to efficiently 
inhibit αIELβ7-mediated adhesion in in vitro assays.

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.
Store undiluted at 4° C and protected from prolonged exposure to light. Do not freeze.