PE-Cy™5 Mouse Anti-Human CD28

产品名称:PE-Cy™5 小鼠抗人 CD28 抗体；PE-Cy™5 Mouse Anti-Human CD28

中文名称:PE-Cy™5 小鼠抗人 CD28 抗体

英文名称:PE-Cy™5 Mouse Anti-Human CD28

PE-Cy™5 Mouse Anti-Human CD28 产品介绍：

Material Number: 555730
Alternate Name: CD28 antigen; T44; Tp44; TP44
Size: 100 Tests
Vol. per Test: 20 µl
Clone: CD28.2
Immunogen: Human CD28 Transfected Cell Line
Isotype: Mouse (C3H x BALB/c) IgG1, κ
Reactivity: QC Testing: Human
Workshop: V 5T CD28.05
Storage Buffer: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.

The CD28.2 monoclonal antibody specifically binds to CD28, a 44 kDa homodimeric transmembrane glycoprotein present on most mature T 
cells, thymocytes and plasma cells. CD28 is a costimulatory receptor that binds CD80 and CD86 as ligands and plays a very important role in 
T cell-B cell interactions. It has been suggested that CD28 initiates and regulates a separate and distinct signal transduction pathway from 
those stimulated by the TCR complex. Additionally, it has been reported that CD28 antibody clones vary in their ability to stimulate T cells to 
produce IL-2 and increase intracellular Ca2+ concentration. This finding suggests the existence of functionally distinct subregions on the 
CD28 molecule. CD28.2 has been demonstrated to bind to the same molecule as clone L293, another CD28 mAb, and has been reported to 
induce Ca2+ influx in Jurkat T cells.

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with PE-Cy5 under optimum conditions, and unconjugated 
antibody and free PE-Cy5 were removed.