产品名称:Recombinant Human IL-12 (p70)
Recombinant Human IL-12 (p70) 产品介绍:
Material Number: 554613 Size: 5 µg Concentration: 100 µg/ml Reactivity: QC Testing: Human Storage Buffer: Frozen aqueous buffered solution containing BSA and glycerol. Recombinant Human IL-12 (p70) Description:
Interleukin-12 (IL-12) is a potent regulator of cell-mediated immune responses. Biologically active IL-12 is secreted by activated B lymphocytes and macrophages as a 70 kD heterodimeric glycoprotein comprised of disulfide-bonded 35 kD (p35) and 40 kD (p40) subunits. The IL-12 p40 monomer shares amino acid sequence homology with the IL-6 receptor. It has been reported that activated PBMC produce a manyfold excess of IL-12 p40 monomer over the bioactive p70 heterodimer. The IL-12 p40 monomer has been reported to inhibit binding of IL-12 p70 to the IL-12 receptor, but with 20X less effectiveness than the IL-12 p70 homodimer. Recombinant human IL-12 p70 (Cat. No. 554613) is supplied as a frozen liquid comprised of 0.22 μm sterile-filtered aqueous buffered solution, containing bovine serum albumin and glycerol, with no preservatives. Purity is ≥ 95% as determined by non-reducing SDS-PAGE, and an absorbance assay based on the Beers-Lambert Law. The endotoxin level is ≤ 0.1 ng per μg of human IL-12 p70, as measured in a chromogenic LAL assay.
Store product at -80°C prior to use or for long term storage of stock solutions. Rapidly thaw and quick-spin product prior to use. Avoid multiple freeze-thaws of product. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
Recombinant Human IL-12 (p70) Suggested Companion Products:
Catalog Number Name Size Clone 555065 Purified Rat Anti-Human IL-12 p70 0.5 mg 20C2 554660 Biotin Mouse Anti-Human IL-12 (p40/p70) 0.5 mg C8.6 555171 Human IL-12 (p40) ELISA Set 20 plates (none) 555183 Human IL-12 (p70) ELISA Set 20 plates (none) 551116 Human IL-12 (p40) ELISA Kit II 2 plates (none) 559258 Human IL-12 (p70) ELISA Kit 2 plates (none)
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